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1

The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds

Báez-Santos, Yahira M., St. John, Sarah E., Mesecar, Andrew D.

Journal:

Antiviral Research

Year:

2015

Language:

english

File:

PDF, 5.69 MB

english, 2015

2

Molecular mechanisms of natural products in chemoprevention: Induction of cytoprotective enzymes by Nrf2

Aimee L. Eggler, Kelly A. Gay, Andrew D. Mesecar

Journal:

Molecular Nutrition & Food Research

Year:

2008

Language:

english

File:

PDF, 1.23 MB

english, 2008

3

The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate

Melissa S Jurica, Andrew Mesecar, Patrick J Heath, Wuxian Shi, Thomas Nowak, Barry L Stoddard

Journal:

Year:

1998

Language:

english

File:

PDF, 1.88 MB

english, 1998

4

Design and Synthesis of Peptidomimetic Severe Acute Respiratory Syndrome Chymotrypsin-like Protease Inhibitors

Ghosh, Arun K., Xi, Kai, Ratia, Kiira, Santarsiero, Bernard D., Fu, Wentao, Harcourt, Brian H., Rota, Paul A., Baker, Susan C., Johnson, Michael E., Mesecar, Andrew D.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 151 KB

english, 2005

5

Potential Cancer Chemopreventive Constituents of the Seeds of Dipteryx o dorata (Tonka Bean)

Jang, Dae Sik, Park, Eun Jung, Hawthorne, Michael E., Vigo, Jose Schunke, Graham, James G., Cabieses, Fernando, Santarsiero, Bernard D., Mesecar, Andrew D., Fong, Harry H. S., Mehta, Rajendra G., Pezz

Journal:

Journal of Natural Products

Year:

2003

Language:

english

File:

PDF, 95 KB

english, 2003

6

Constituents of Musa × paradisiaca Cultivar with the Potential To Induce the Phase II Enzyme, Quinone Reductase

Jang, Dae Sik, Park, Eun Jung, Hawthorne, Michael E., Vigo, Jose Schunke, Graham, James G., Cabieses, Fernando, Santarsiero, Bernard D., Mesecar, Andrew D., Fong, Harry H. S., Mehta, Rajendra G., Pezz

Journal:

Journal of Agricultural and Food Chemistry

Year:

2002

Language:

english

File:

PDF, 79 KB

english, 2002

7

Pleiotropic mechanisms facilitated by resveratrol and its metabolites

Calamini, Barbara, Ratia, Kiira, Malkowski, Michael G., Cuendet, Muriel, Pezzuto, John M., Santarsiero, Bernard D., Mesecar, Andrew D.

Journal:

Biochemical Journal

Year:

2010

Language:

english

File:

PDF, 1.01 MB

english, 2010

8

Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CL pro )

Tomar, Sakshi, Johnston, Melanie L., St. John, Sarah E., Osswald, Heather L., Nyalapatla, Prasanth R., Paul, Lake N., Ghosh, Arun K., Denison, Mark R., Mesecar, Andrew D.

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 5.78 MB

english, 2015

9

ChemInform Abstract: An Oxyanion-Hole Selective Serine Protease Inhibitor in Complex with Trypsin.

Jian Cui, Fatima Marankan, Wentao Fu, David Crich, Andrew Mesecar, Michael E. Johnson

Journal:

Year:

2002

File:

PDF, 30 KB

2002

10

Vitexlactam A, a Novel Labdane Diterpene Lactam from the Fruits of Vitex agnus-castus.

Sheng-Hong Li, Hong-Jie Zhang, Sheng-Xiang Qiu, Xue-Mei Niu, Bernard D. Santarsiero, Andrew D. Mesecar, Harry H. S. Fong, Norman R. Farnsworth, Han-Dong Sun

Journal:

Year:

2002

File:

PDF, 26 KB

2002

11

Isolation and Absolute Stereochemistry of Coussaric Acid, a New Bioactive Triterpenoid from the Stems of Coussarea brevicaulis.

Bao-Ning Su, Young-Hwa Kang, Rosa Elena Pinos, Bernard D. Santarsiero, Andrew D. Mesecar, D. Doel Soejarto, Harry H. S. Fong, John M. Pezzuto, A. Douglas Kinghorn

Journal:

Year:

2004

File:

PDF, 73 KB

2004

12

Design, Syntheis, and Evaluation of Oxyanion-Hole Selective Inhibitor Substituents for the S1 Subsite of Factor Xa.

Sochanchingwung Rumthao, Oukseub Lee, Qi Sheng, WenTao Fu, Debbie C. Mulhearn, David Crich, Andrew D. Mesecar, Michael E. Johnson

Journal:

Year:

2005

File:

PDF, 23 KB

2005

13

Identification of a Glycogen Synthase Kinase-3β Inhibitor that Attenuates Hyperactivity in CLOCK Mutant Mice

Prof. Alan P. Kozikowski, Dr. Hendra Gunosewoyo, Dr. Songpo Guo, Dr. Irina N. Gaisina, Dr. Richard L. Walter, Ariel Ketcherside, Prof. Colleen A. McClung, Prof. Andrew D. Mesecar, Dr. Barbara Caldaron

Journal:

Year:

2011

Language:

english

File:

PDF, 1005 KB

english, 2011

14

Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity

Tamara P. Kondratyuk, Eun-Jung Park, Laura E. Marler, Soyoun Ahn, Yang Yuan, Yongsoo Choi, Rui Yu, Richard B. van Breemen, Bin Sun, Juma Hoshino, Mark Cushman, Katherine C. Jermihov, Andrew D. Mesecar

Journal:

Molecular Nutrition & Food Research

Year:

2011

Language:

english

File:

PDF, 303 KB

english, 2011

15

Activity-guided isolation of cytotoxic constituents from the bark of Aglaia crassinervia collected in Indonesia

Bao-Ning Su, Heebyung Chai, Qiuwen Mi, Soedarsono Riswan, Leonardus B.S. Kardono, Johar J. Afriastini, Bernard D. Santarsiero, Andrew D. Mesecar, Norman R. Farnsworth, Geoffrey A. Cordell, Steven M. S

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 287 KB

english, 2006

16

Design, synthesis, and evaluation of oxyanion-hole selective inhibitor substituents for the S1 subsite of factor Xa

Sochanchingwung Rumthao, Oukseub Lee, Qi Sheng, WenTao Fu, Debbie C. Mulhearn, David Crich, Andrew D. Mesecar, Michael E. Johnson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 385 KB

english, 2004

17

Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors

Arun K. Ghosh, Gangli Gong, Valerie Grum-Tokars, Debbie C. Mulhearn, Susan C. Baker, Melissa Coughlin, Bellur S. Prabhakar, Katrina Sleeman, Michael E. Johnson, Andrew D. Mesecar

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 472 KB

english, 2008

18

Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer

Bin Sun, Juma Hoshino, Katie Jermihov, Laura Marler, John M. Pezzuto, Andrew D. Mesecar, Mark Cushman

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.38 MB

english, 2010

19

Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors

Arun K. Ghosh, Kai Xi, Valerie Grum-Tokars, Xiaoming Xu, Kiira Ratia, Wentao Fu, Katherine V. Houser, Susan C. Baker, Michael E. Johnson, Andrew D. Mesecar

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 254 KB

english, 2007

20

Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase

Suresh K. Tipparaju, Sipak Joyasawal, Sara Forrester, Debbie C. Mulhearn, Scott Pegan, Michael E. Johnson, Andrew D. Mesecar, Alan P. Kozikowski

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 396 KB

english, 2008

21

Sites of Alkylation of Human Keap1 by Natural Chemoprevention Agents

Yan Luo, Aimee L. Eggler, Dongting Liu, Guowen Liu, Andrew D. Mesecar, Richard B. van Breemen

Journal:

Journal of the American Society for Mass Spectrometry

Year:

2007

Language:

english

File:

PDF, 216 KB

english, 2007

22

Isolation and evaluation of kaempferol glycosides from the fern Neocheiropteris palmatopedata

Jian-Hong Yang, Tamara P. Kondratyuk, Laura E. Marler, Xi Qiu, Yongsoo Choi, Hongmei Cao, Rui Yu, Megan Sturdy, Scott Pegan, Ying Liu, Li-Qin Wang, Andrew D. Mesecar, Richard B. Van Breemen, John M. P

Journal:

Year:

2010

Language:

english

File:

PDF, 337 KB

english, 2010

23

Isolation and absolute stereochemistry of coussaric acid, a new bioactive triterpenoid from the stems of Coussarea brevicaulis

Bao-Ning Su, Young-Hwa Kang, Rosa Elena Pinos, Bernard D. Santarsiero, Andrew D. Mesecar, D.Doel Soejarto, Harry H.S. Fong, John M. Pezzuto, A.Douglas Kinghorn

Journal:

Year:

2003

Language:

english

File:

PDF, 387 KB

english, 2003

24

Isolation and characterization of bioactive principles of the leaves and stems of Physalis philadelphica

Bao-Ning Su, Rosana Misico, Eun Jung Park, Bernard D Santarsiero, Andrew D Mesecar, Harry H.S Fong, John M Pezzuto, A Douglas Kinghorn

Journal:

Year:

2002

Language:

english

File:

PDF, 259 KB

english, 2002

25

Vitexlactam A, a novel labdane diterpene lactam from the fruits of Vitex agnus-castus

Sheng-Hong Li, Hong-Jie Zhang, Sheng-Xiang Qiu, Xue-Mei Niu, Bernard D. Santarsiero, Andrew D. Mesecar, Harry H.S. Fong, Norman R. Farnsworth, Han-Dong Sun

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 146 KB

english, 2002

26

An oxyanion-Hole selective serine protease inhibitor in complex with trypsin

Jian Cui, Fatima Marankan, Wentao Fu, David Crich, Andrew Mesecar, Michael E Johnson

Journal:

Bioorganic & Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 245 KB

english, 2002

27

GABAergic phthalide dimers from Angelica sinensis (Oliv.) Diels

Shixin Deng, Shao-Nong Chen, Jian Lu, Zaijie Jim Wang, Dejan Nikolic, Richard B. van Breemen, Bernard D. Santarsiero, Andrew Mesecar, Harry H.S. Fong, Norman R. Farnsworth, Guido F. Pauli

Journal:

Phytochemical Analysis

Year:

2006

Language:

english

File:

PDF, 212 KB

english, 2006

28

X-ray structural studies of quinone reductase 2 nanomolar range inhibitors

Scott D. Pegan, Megan Sturdy, Gilles Ferry, Philippe Delagrange, Jean A. Boutin, Andrew D. Mesecar

Journal:

Protein Science

Year:

2011

Language:

english

File:

PDF, 893 KB

english, 2011

29

Characterization of novelrad6/ubc2ubiquitin-conjugating enzyme mutants in yeast

Gail Freiberg, Andrew D. Mesecar, Hanhua Huang, Joo Yun Hong, Susan W. Liebman

Journal:

Current Genetics

Year:

2000

Language:

english

File:

PDF, 471 KB

english, 2000

30

Use of molecular modeling, docking, and 3D-QSAR studies for the determination of the binding mode of benzofuran-3-yl-(indol-3-yl)maleimides as GSK-3β inhibitors

Ki Hwan Kim, Irina Gaisina, Franck Gallier, Denise Holzle, Sylvie Y. Blond, Andrew Mesecar, Alan P. Kozikowski

Journal:

Journal of Molecular Modeling

Year:

2009

Language:

english

File:

PDF, 1.27 MB

english, 2009

31

Natural product leads for drug discovery: Isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents

Songpo Guo, Suresh K. Tipparaju, Scott D. Pegan, Baojie Wan, Shunyan Mo, Jimmy Orjala, Andrew D. Mesecar, Scott G. Franzblau, Alan P. Kozikowski

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 317 KB

english, 2009

32

Millisecond Laue structures of an enzyme–product complex using photocaged substrate analogs

Stoddard, Barry L., Cohen, Bruce E., Brubaker, Michael, Mesecar, Andrew D., Koshland Jr, Daniel E.

Journal:

Natural Structural Biology

Year:

1998

Language:

english

File:

PDF, 305 KB

english, 1998

33

10.1038/35001144

Koshland, Daniel E., Mesecar, Andrew D.

Journal:

Year:

2000

Language:

english

File:

PDF, 355 KB

english, 2000

34

An ELISA method to measure inhibition of the COX enzymes

Cuendet, Muriel, Mesecar, Andrew D, DeWitt, David L, Pezzuto, John M

Journal:

Nature Protocols

Year:

2006

Language:

english

File:

PDF, 300 KB

english, 2006

35

Structural Basis for Tumor Pyruvate Kinase M2 Allosteric Regulation and Catalysis†,‡

Dombrauckas, Jill D., Santarsiero, Bernard D., Mesecar, Andrew D.

Journal:

Year:

2005

Language:

english

File:

PDF, 700 KB

english, 2005

36

Sites of Binding and Orientation in a Four-Location Model for Protein Stereospecificity

Andrew D. Mesecar, Daniel E. Koshland Jr.

Journal:

Year:

2000

Language:

english

File:

PDF, 808 KB

english, 2000

37

New Sesquiterpenes from Litsea verticillata

Zhang, Hong-Jie, Tan, Ghee Teng, Santarsiero, Bernard D., Mesecar, Andrew D., Hung, Nguyen Van, Cuong, Nguyen Manh, Doel Soejarto, D., Pezzuto, John M., Fong, Harry H. S.

Journal:

Journal of Natural Products

Year:

2003

Language:

english

File:

PDF, 157 KB

english, 2003

38

Screening for natural chemoprevention agents that modify human Keap1

Chenqi Hu, Dejan Nikolic, Aimee L. Eggler, Andrew D. Mesecar, Richard B. van Breemen

Journal:

Analytical Biochemistry

Year:

2012

Language:

english

File:

PDF, 398 KB

english, 2012

39

Genetic interaction between yeast Saccharomyces cerevisiae release factors and the decoding region of 18 S rRNA

Irina V. Velichutina, Joo Yun Hong, Andrew D. Mesecar, Yury O. Chernoff, Susan W. Liebman

Journal:

Journal of Molecular Biology

Year:

2001

Language:

english

File:

PDF, 4.29 MB

english, 2001

40

Structural and mutational studies of organophosphorus hydrolase reveal a cryptic and functional allosteric-binding site

Janet K. Grimsley, Barbara Calamini, James R. Wild, Andrew D. Mesecar

Journal:

Archives of Biochemistry and Biophysics

Year:

2005

Language:

english

File:

PDF, 588 KB

english, 2005

41

The structures of T87I phosphono-CheY and T87I/Y106W phosphono-CheY help to explain their binding affinities to the FliM and CheZ peptides

Kenneth McAdams, Eric S. Casper, R. Matthew Haas, Bernard D. Santarsiero, Aimee L. Eggler, Andrew Mesecar, Christopher J. Halkides

Journal:

Archives of Biochemistry and Biophysics

Year:

2008

Language:

english

File:

PDF, 901 KB

english, 2008

42

Structural basis for thermostability revealed through the identification and characterization of a highly thermostable phosphotriesterase-like lactonase from Geobacillus stearothermophilus

Renda Hawwa, John Aikens, Robert J. Turner, Bernard D. Santarsiero, Andrew D. Mesecar

Journal:

Archives of Biochemistry and Biophysics

Year:

2009

Language:

english

File:

PDF, 1.29 MB

english, 2009

43

Development of an efficient E. coli expression and purification system for a catalytically active, human Cullin3–RINGBox1 protein complex and elucidation of its quaternary structure with Keap1

Evan Small, Aimee Eggler, Andrew D. Mesecar

Journal:

Biochemical and Biophysical Research Communications

Year:

2010

Language:

english

File:

PDF, 399 KB

english, 2010

44

Structural and Functional Analysis of Two Glutamate Racemase Isozymes from Bacillus anthracis and Implications for Inhibitor Design

Melissa May, Shahila Mehboob, Debbie C. Mulhearn, Zhiqiang Wang, Huidong Yu, Gregory R.J. Thatcher, Bernard D. Santarsiero, Michael E. Johnson, Andrew D. Mesecar

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 4.29 MB

english, 2007

45

Kinetic and X-Ray Structural Evidence for Negative Cooperativity in Substrate Binding to Nicotinate Mononucleotide Adenylyltransferase (NMAT) from Bacillus anthracis

Valerie C. Sershon, Bernard D. Santarsiero, Andrew D. Mesecar

Journal:

Journal of Molecular Biology

Year:

2009

Language:

english

File:

PDF, 1.64 MB

english, 2009

46

Structural Basis for Catalysis of a Tetrameric Class IIa Fructose 1,6-Bisphosphate Aldolase from Mycobacterium tuberculosis

Scott D. Pegan, Kamolchanok Rukseree, Scott G. Franzblau, Andrew D. Mesecar

Journal:

Journal of Molecular Biology

Year:

2009

Language:

english

File:

PDF, 1.47 MB

english, 2009

47

Structure-Based and Random Mutagenesis Approaches Increase the Organophosphate-Degrading Activity of a Phosphotriesterase Homologue from Deinococcus radiodurans

Renda Hawwa, Sonia D. Larsen, Kiira Ratia, Andrew D. Mesecar

Journal:

Journal of Molecular Biology

Year:

2009

Language:

english

File:

PDF, 2.33 MB

english, 2009

48

Kinetic, Thermodynamic, and Structural Insight into the Mechanism of Phosphopantetheine Adenylyltransferase from Mycobacterium tuberculosis

Thomas J. Wubben, Andrew D. Mesecar

Journal:

Journal of Molecular Biology

Year:

2010

Language:

english

File:

PDF, 1.77 MB

english, 2010

49

Evaluating the 3C-like protease activity of SARS-Coronavirus: Recommendations for standardized assays for drug discovery

Valerie Grum-Tokars, Kiira Ratia, Adrian Begaye, Susan C. Baker, Andrew D. Mesecar

Journal:

Year:

2008

Language:

english

File:

PDF, 1.04 MB

english, 2008

50

Black Cohosh Acts as a Mixed Competitive Ligand and Partial Agonist of the Serotonin Receptor

Burdette, Joanna E., Liu, Jianghua, Chen, Shao-nong, Fabricant, Daniel S., Piersen, Colleen E., Barker, Eric L., Pezzuto, John M., Mesecar, Andrew, van Breemen, Richard B., Farnsworth, Norman R., Bolt

Journal:

Journal of Agricultural and Food Chemistry

Year:

2003

Language:

english

File:

PDF, 128 KB

english, 2003